Melatonin impairment has been implicated in autism
If one recognizes that heavy metals play a part in the modern-day epidemic of neurological diseases, then part of the explanation for the sleep disorders encountered in various neurological diseases may be that both aluminum and mercury (thimerosal) disrupt the pineal gland and its ability to make sulfate. When the pineal gland's ability to make sulfate is impaired, this, in turn, reduces production of melatonin, all-important for adequate and healthy sleep. The pineal gland is particularly susceptible to aluminum and other heavy metals because it is not protected by the blood-brain barrier and has a very high blood perfusion rate.
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=> La glande pinéale est déréglée par les ML. Quand cette glande est déréglée, la production de mélatonine est perturbée.
The Role of Sunlight
Returning once again to the topic of sulfate, Dr. Seneff underscored the important and neglected fact that sunlight is absolutely essential for human health because of its role in catalyzing sulfate production. We will be sulfate-deficient if we do not get enough sun. The pineal gland plays an important role in this process. Specifically, endothelial and neuronal nitric oxide synthase—both of which are present in the pineal gland—produce sulfate from reduced sulfur sources catalyzed by sunlight.
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=> La vitamine D est primordiale car c'est un catalyseur de la fabrication de sulfates (soufre).
Role of vitamin D
One of the ways that the protective effect of sunlight exposure makes sense is recognizing the critical role that vitamin D plays in sulfate homeostasis. A study in mice found that activated vitamin D prevented sulfate wasting from the kidney in urine, and mice engineered to have defective vitamin D receptors (or with vitamin D deficiency) had significantly reduced serum sulfate levels, which were associated with sulfate depletion in the skeleton. Children with autism have high sulfate in their urine but low serum sulfate levels, which clearly indicates both generic sulfate deficiency and vitamin D deficiency.
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Glyphosate: The Elephant in the Room
Dr. Seneff began paying attention to glyphosate after she had been intensely researching autism for five or six years. Glyphosate is a broad-spectrum systemic herbicide (known to the world under its trade name Roundup®). Among its many nefarious health effects, glyphosate disrupts the way the body manages sulfur.
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Both glyphosate and autism are associated with low melatonin, impaired sulfur metabolism (and low serum sulfate), low vitamin D, sleep disorders, disrupted gut bacteria, and more.
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Glyphosate—already a very dangerous chemical on its own—causes aluminum to be much more toxic. Glyphosate and aluminum can be viewed as "partners in crime," working synergistically with one another. This partnership plays out in several ways:
1. First, glyphosate preferentially kills beneficial bacteria in the gut, which allows pathogens such as C. difficile to overgrow. Not only does this lead to leaky gut syndrome, but C. difficile produces something called p-Cresol, a phenolic compound that is toxic to other microbes via its ability to interfere with metabolism. (…)
2. Glyphosate also serves to increase aluminum toxicity by "caging" aluminum to promote its entry into the body. Glyphosate promotes calcium uptakeby voltage-activated channels, which allow aluminum to gain entry as a calcium mimetic. Aluminum then promotes calcium loss from bones, contributing to pineal gland calcification.
3. Bringing melatonin back into the discussion, glyphosate interferes with what is known as the shikimate pathway. Although humans do not have the shikimate pathway, our gut flora do, and we depend on our gut flora to supply us with essential amino acids and many other things. Disruption of the shikimate pathway in our gut results in depletion of tryptophan, which is the sole precursor to melatonin. Besides needing melatonin to transport sulfate into the brain, we also need melatonin to reduce heavy metal toxicity. Where supplies of melatonin are adequate, melatonin will bind to aluminum, cadmium, copper, iron, and lead, and reduce their toxicity. Where melatonin is low, a lot of damage can result.
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Dr. Seneff believes that when children are overexposed to glyphosate, especially through consumption of the GM foods (OGM) that are widely prevalent in the American diet, they are more likely to react badly to vaccination.
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Summary
Taken together, the body of evidence elegantly assembled by Dr. Seneff supports her hypothesis that the epidemic levels of autism (and other diseases such as Alzheimer's disease) currently seen in the Western world are caused by a severe deficiency in sulfate supplies to the brain. Under optimal circumstances, the pineal gland can synthesize sulfate stimulated by sunlight and deliver it via melatonin sulfate to the brain. However, aluminum, mercury, and glyphosate are working synergistically to derail this process, and sunlight deficiency (exacerbated by the misguided use of sunscreens containing aluminum nanoparticles) is further contributing to the pathology.
http://articles.mercola.com/sites/artic ... =513563530" onclick="window.open(this.href);return false;
Source:
Claire Viadro, MPH, PhD.
